Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Helmann JD
PROVIDER: S-EPMC4192466 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
The Journal of biological chemistry 20140826 41
Metalloregulatory proteins allow cells to sense metal ions and appropriately adjust the expression of metal uptake, storage, and efflux pathways. Bacillus subtilis provides a model for the coordinate regulation of iron and manganese homeostasis that involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio. Here, I review the structural and physiological bases of selective metal perception, the effects of non-cogn ...[more]
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