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ABSTRACT: Objective
We elected to analyze the correlation between the pre-treatment apparent diffusion coefficient (ADC) and the clinical, histological, and immunohistochemical status of rectal cancers.Materials and methods
Forty-nine rectal cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI and diffusion-weighted imaging (DWI). Tumor ADC values were determined and analyzed to identify any correlations between these values and pre-treatment CEA or CA19-9 levels, and/or the histological and immunohistochemical properties of the tumor.Results
Inter-observer agreement of confidence levels from two separate observers was suitable for ADC measurement (k ?=? 0.775). The pre-treatment ADC values of different T stage tumors were not equal (p ?=? 0.003). The overall trend was that higher T stage values correlated with lower ADC values. ADC values were also significantly lower for the following conditions: tumors with the presence of extranodal tumor deposits (p ?=? 0.006) and tumors with CA19-9 levels ? 35 g/ml (p ?=? 0.006). There was a negative correlation between Ki-67 LI and the ADC value (r ?=? -0.318, p ?=? 0.026) and between the AgNOR count and the ADC value (r ?=? -0.310, p ?=? 0.030).Conclusion
Significant correlations were found between the pre-treatment ADC values and T stage, extranodal tumor deposits, CA19-9 levels, Ki-67 LI, and AgNOR counts in our study. Lower ADC values were associated with more aggressive tumor behavior. Therefore, the ADC value may represent a useful biomarker for assessing the biological features and possible relationship to the status of identified rectal cancers.
SUBMITTER: Sun Y
PROVIDER: S-EPMC4193754 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sun Yiqun Y Tong Tong T Cai Sanjun S Bi Rui R Xin Chao C Gu Yajia Y
PloS one 20141010 10
<h4>Objective</h4>We elected to analyze the correlation between the pre-treatment apparent diffusion coefficient (ADC) and the clinical, histological, and immunohistochemical status of rectal cancers.<h4>Materials and methods</h4>Forty-nine rectal cancer patients who received surgical resection without neoadjuvant therapy were selected that underwent primary MRI and diffusion-weighted imaging (DWI). Tumor ADC values were determined and analyzed to identify any correlations between these values a ...[more]