Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC4193957 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Liu Hongde H Zhai Jinchen J Luo Kun K Liu Lingjie L
BMC molecular biology 20141005
<h4>Background</h4>Previous studies suggested that nucleosomes are enriched with single nucleotide polymorphisms (SNPs) in humans and that the occurrence of mutations is closely associated with CpG dinucleotides. We aimed to determine if the chromatin organization is genomic locus specific around SNPs, and if newly occurring mutations are associated with SNPs.<h4>Results</h4>Here, we classified SNPs according their loci and investigated chromatin organization in both CD4+ T cell and lymphoblasto ...[more]