Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.
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ABSTRACT:
SUBMITTER: Chen JC
PROVIDER: S-EPMC4194029 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.
Chen James C JC Alvarez Mariano J MJ Talos Flaminia F Dhruv Harshil H Rieckhof Gabrielle E GE Iyer Archana A Diefes Kristin L KL Aldape Kenneth K Berens Michael M Shen Michael M MM Shen Michael M MM Califano Andrea A
Cell 20141001 2
Identification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a framework for the systematic discovery of genetic alterations that are causal determinants of disease, by prioritizing genes upstream of functional disease drivers, within regulatory networks inferred de novo from experimental data. We tested this framework by identifying the genetic determinants of the mesenchymal subtype of glioblastoma. Our anal ...[more]
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