Ontology highlight
ABSTRACT:
SUBMITTER: Meisel JD
PROVIDER: S-EPMC4194030 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Meisel Joshua D JD Panda Oishika O Mahanti Parag P Schroeder Frank C FC Kim Dennis H DH
Cell 20141001 2
Discrimination between pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa modulates a neuroendocrine signaling pathway that promotes avoidance behavior in the simple animal host Caenorhabditis elegans. Secondary metabolites phenazine-1-carboxamide and pyochelin activate a G-protein-signaling pathway in the ASJ chemosensory neuron pair that induces exp ...[more]