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Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans.


ABSTRACT: Discrimination between pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa modulates a neuroendocrine signaling pathway that promotes avoidance behavior in the simple animal host Caenorhabditis elegans. Secondary metabolites phenazine-1-carboxamide and pyochelin activate a G-protein-signaling pathway in the ASJ chemosensory neuron pair that induces expression of the neuromodulator DAF-7/TGF-?. DAF-7, in turn, activates a canonical TGF-? signaling pathway in adjacent interneurons to modulate aerotaxis behavior and promote avoidance of pathogenic P. aeruginosa. Our data provide a chemical, genetic, and neuronal basis for how the behavior and physiology of a simple animal host can be modified by the microbial environment and suggest that secondary metabolites produced by microbes may provide environmental cues that contribute to pathogen recognition and host survival.

SUBMITTER: Meisel JD 

PROVIDER: S-EPMC4194030 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans.

Meisel Joshua D JD   Panda Oishika O   Mahanti Parag P   Schroeder Frank C FC   Kim Dennis H DH  

Cell 20141001 2


Discrimination between pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa modulates a neuroendocrine signaling pathway that promotes avoidance behavior in the simple animal host Caenorhabditis elegans. Secondary metabolites phenazine-1-carboxamide and pyochelin activate a G-protein-signaling pathway in the ASJ chemosensory neuron pair that induces exp  ...[more]

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