Ontology highlight
ABSTRACT:
SUBMITTER: Banzhaf-Strathmann J
PROVIDER: S-EPMC4194100 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Banzhaf-Strathmann Julia J Benito Eva E May Stephanie S Arzberger Thomas T Tahirovic Sabina S Kretzschmar Hans H Fischer André A Edbauer Dieter D
The EMBO journal 20140707 15
Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear disease-initiating mechanism is known. Aβ deposits and neuronal tangles composed of hyperphosphorylated tau are characteristic for AD. Here, we analyze the contribution of microRNA-125b (miR-125b), which is elevated in AD. In primary neurons, overexpression of miR-125b causes tau hyperphosphorylation and an upregulation of p35, cdk5, and p44/42-MAPK signaling. In parallel, the phosphatases DUSP6 and PPP1CA and ...[more]