Ontology highlight
ABSTRACT:
SUBMITTER: Lackford B
PROVIDER: S-EPMC4194112 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Lackford Brad B Yao Chengguo C Charles Georgette M GM Weng Lingjie L Zheng Xiaofeng X Choi Eun-A EA Xie Xiaohui X Wan Ji J Xing Yi Y Freudenberg Johannes M JM Yang Pengyi P Jothi Raja R Hu Guang G Shi Yongsheng Y
The EMBO journal 20140304 8
mRNA alternative polyadenylation (APA) plays a critical role in post-transcriptional gene control and is highly regulated during development and disease. However, the regulatory mechanisms and functional consequences of APA remain poorly understood. Here, we show that an mRNA 3' processing factor, Fip1, is essential for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Fip1 promotes stem cell maintenance, in part, by activating the ESC-specific APA profiles to ensure the opt ...[more]