Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.
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ABSTRACT:
SUBMITTER: Wang CM
PROVIDER: S-EPMC4194124 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.
Wang Chiuhui Mary CM Ploia Cristina C Anselmi Fabio F Sarukhan Adelaida A Viola Antonella A
The EMBO journal 20140519 12
Organization of immune responses requires exchange of information between cells. This is achieved through either direct cell-cell contacts and establishment of temporary synapses or the release of soluble factors, such as cytokines and chemokines. Here we show a novel form of cell-to-cell communication based on adenosine triphosphate (ATP). ATP released by stimulated T cells induces P2X4/P2X7-mediated calcium waves in the neighboring lymphocytes. Our data obtained in lymph node slices suggest th ...[more]
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