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Bacteria from diverse habitats colonize and compete in the mouse gut.

ABSTRACT: To study how microbes establish themselves in a mammalian gut environment, we colonized germ-free mice with microbial communities from human, zebrafish, and termite guts, human skin and tongue, soil, and estuarine microbial mats. Bacteria from these foreign environments colonized and persisted in the mouse gut; their capacity to metabolize dietary and host carbohydrates and bile acids correlated with colonization success. Cohousing mice harboring these xenomicrobiota or a mouse cecal microbiota, along with germ-free "bystanders," revealed the success of particular bacterial taxa in invading guts with established communities and empty gut habitats. Unanticipated patterns of ecological succession were observed; for example, a soil-derived bacterium dominated even in the presence of bacteria from other gut communities (zebrafish and termite), and human-derived bacteria colonized germ-free bystander mice before mouse-derived organisms. This approach can be generalized to address a variety of mechanistic questions about succession, including succession in the context of microbiota-directed therapeutics.

SUBMITTER: Seedorf H

PROVIDER: S-EPMC4194163 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Bacteria from diverse habitats colonize and compete in the mouse gut.

Seedorf Henning H Griffin Nicholas W NW Ridaura Vanessa K VK Reyes Alejandro A Cheng Jiye J Rey Federico E FE Smith Michelle I MI Simon Gabriel M GM Scheffrahn Rudolf H RH Woebken Dagmar D Spormann Alfred M AM Van Treuren William W Ursell Luke K LK Pirrung Megan M Robbins-Pianka Adam A Cantarel Brandi L BL Lombard Vincent V Henrissat Bernard B Knight Rob R Gordon Jeffrey I JI

Cell 20141002 2

To study how microbes establish themselves in a mammalian gut environment, we colonized germ-free mice with microbial communities from human, zebrafish, and termite guts, human skin and tongue, soil, and estuarine microbial mats. Bacteria from these foreign environments colonized and persisted in the mouse gut; their capacity to metabolize dietary and host carbohydrates and bile acids correlated with colonization success. Cohousing mice harboring these xenomicrobiota or a mouse cecal microbiota, ...[more]

PMID: 25284151

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Bacteria from diverse habitats colonize and compete in the mouse gut.

Publications

Bacteria from diverse habitats colonize and compete in the mouse gut.

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