Ontology highlight
ABSTRACT:
SUBMITTER: Roccaro AM
PROVIDER: S-EPMC4194173 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Roccaro Aldo M AM Sacco Antonio A Purschke Werner G WG Moschetta Michele M Buchner Klaus K Maasch Christian C Zboralski Dirk D Zöllner Stefan S Vonhoff Stefan S Mishima Yuji Y Maiso Patricia P Reagan Michaela R MR Lonardi Silvia S Ungari Marco M Facchetti Fabio F Eulberg Dirk D Kruschinski Anna A Vater Axel A Rossi Giuseppe G Klussmann Sven S Ghobrial Irene M IM
Cell reports 20140925 1
Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as multiple myeloma (MM). Targeting the BM niche to prevent or modulate metastasis has not been successful to date. Here, we show that stromal cell-derived factor-1 (SDF-1/CXCL12) is highly expressed in active MM, as well as in BM sites of tumor metastasis and report on the discovery of the high-affinity anti-SDF-1 PEGylated mirror-image l-oligonucleotide (olaptesed-pegol). In vivo confocal i ...[more]