Ontology highlight
ABSTRACT:
SUBMITTER: Suwal S
PROVIDER: S-EPMC4194856 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Suwal Sujit S Kodadek Thomas T
Organic & biomolecular chemistry 20130401 13
Peptoid libraries have been shown to be a useful source of protein-binding agents. However, simple linear peptoids lack conformational constraints, which may limit their binding affinity for proteins. Here we report facile chemistry for the assembly of 2-oxopiperazine rings into the main chain of peptoid-like oligomers, thus rigidifying the structure. This modified sub-monomer synthesis is suitable for the creation of high quality combinatorial libraries. ...[more]