Ontology highlight
ABSTRACT:
SUBMITTER: Bian Z
PROVIDER: S-EPMC4195386 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140929 40
The concise, enantioselective total syntheses of (-)-citrinadin A and (+)-citrinadin B in a total of only 20 and 21 steps, respectively, from commercially available starting materials are described. Our strategy, which minimizes refunctionalization and protection/deprotection operations, features the highly diastereoselective, vinylogous Mannich addition of a dienolate to a chiral pyridinium salt to set the first chiral center. The absolute stereochemistry of this key center was then relayed by ...[more]