Ontology highlight
ABSTRACT:
SUBMITTER: Arnoult D
PROVIDER: S-EPMC419544 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Arnoult Damien D Bartle Laura M LM Skaletskaya Anna A Poncet Delphine D Zamzami Naoufal N Park Peter U PU Sharpe Juanita J Youle Richard J RJ Goldmacher Victor S VS
Proceedings of the National Academy of Sciences of the United States of America 20040517 21
We report that the cytomegalovirus-encoded cell death suppressor vMIA binds Bax and prevents Bax-mediated mitochondrial membrane permeabilization by sequestering Bax at mitochondria in the form of a vMIA-Bax complex. vMIA mutants with a defective mitochondria-targeting domain retain their Bax-binding function but not their ability to suppress mitochondrial membrane permeabilization or cell death. vMIA does not seem to either specifically associate with Bak or suppress Bak-mediated mitochondrial ...[more]