Ontology highlight
ABSTRACT:
SUBMITTER: Poirot L
PROVIDER: S-EPMC419564 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Poirot Laurent L Benoist Christophe C Mathis Diane D
Proceedings of the National Academy of Sciences of the United States of America 20040512 21
In both human patients and murine models, the progression from insulitis to diabetes is neither immediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of BDC2.5 transgenic mice on the nonobese diabetic (NOD) versus C57BL/6.H-2g7 genetic backgrounds. Natural killer (NK)-cell-specific transcripts and the proportion of NK cells were increased in leukocytes from the aggressive BDC2.5/B6.H-2g7 lesions. NK cell participation was also enhanced in the aggressive lesions ...[more]