Ontology highlight
ABSTRACT:
SUBMITTER: Koike T
PROVIDER: S-EPMC419569 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Koike Tetsufumi T Kimura Naoko N Miyazaki Keiko K Yabuta Tomonori T Kumamoto Kensuke K Takenoshita Seiichi S Chen Jian J Kobayashi Masanobu M Hosokawa Masuo M Taniguchi Akiyoshi A Kojima Tetsuhito T Ishida Nobuhiro N Kawakita Masao M Yamamoto Harumi H Takematsu Hiromu H Suzuki Akemi A Kozutsumi Yasunori Y Kannagi Reiji R
Proceedings of the National Academy of Sciences of the United States of America 20040512 21
Cancer cells undergo distinct metabolic changes to cope with their hypoxic environment. These changes are achieved at least partly by the action of transcriptional factors called hypoxia-inducible factors (HIFs). We investigated gene expression in cultured human colon cancer cells induced by hypoxic conditions with special reference to cell-adhesion molecules and carbohydrate determinants having cell-adhesive activity by using DNA-microarray and RT-PCR techniques. Hypoxic culture of colon cancer ...[more]