Ontology highlight
ABSTRACT:
SUBMITTER: Peacock O
PROVIDER: S-EPMC4195713 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Peacock Oliver O Lee Andrew C AC Cameron Fraser F Tarbox Rebecca R Vafadar-Isfahani Natasha N Tufarelli Cristina C Lund Jonathan N JN
PloS one 20141013 10
Inflammation plays a direct role in colorectal cancer (CRC) progression; however the molecular mechanisms responsible for this effect are unclear. The inflammation induced cyclooxygenase 2 (COX-2) enzyme required for the production of Prostaglandin E2 (PGE2), can promote colorectal cancer by decreasing expression of the tumour suppressor gene Programmed Cell Death 4 (PDCD4). As PDCD4 is also a direct target of the oncogene microRNA-21 (miR-21) we investigated the relationship between the COX-2 a ...[more]