Ontology highlight
ABSTRACT:
SUBMITTER: Elharar Y
PROVIDER: S-EPMC4195762 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Elharar Yifat Y Roth Ziv Z Hermelin Inna I Moon Alexandra A Peretz Gabriella G Shenkerman Yael Y Vishkautzan Marina M Khalaila Isam I Gur Eyal E
The EMBO journal 20140701 16
Intracellular protein degradation is an essential process in all life domains. While in all eukaryotes regulated protein degradation involves ubiquitin tagging and the 26S-proteasome, bacterial prokaryotic ubiquitin-like protein (Pup) tagging and proteasomes are conserved only in species belonging to the phyla Actinobacteria and Nitrospira. In Mycobacterium tuberculosis, the Pup-proteasome system (PPS) is important for virulence, yet its physiological role in non-pathogenic species has remained ...[more]