Ontology highlight
ABSTRACT:
SUBMITTER: Yu S
PROVIDER: S-EPMC4195784 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Yu Shiyan S Nie Yingchao Y Knowles Byron B Sakamori Ryotaro R Stypulkowski Ewa E Patel Chirag C Das Soumyashree S Douard Veronique V Ferraris Ronaldo P RP Bonder Edward M EM Goldenring James R JR Ip Yicktung Tony YT Gao Nan N
The EMBO journal 20140724 17
Compartmentalization of Toll-like receptors (TLRs) in intestinal epithelial cells (IECs) regulates distinct immune responses to microbes; however, the specific cellular machinery that controls this mechanism has not been fully identified. Here we provide genetic evidences that the recycling endosomal compartment in enterocytes maintains a homeostatic TLR9 intracellular distribution, supporting mucosal tolerance to normal microbiota. Genetic ablation of a recycling endosome resident small GTPase, ...[more]