Ontology highlight
ABSTRACT:
SUBMITTER: van Thuijl HF
PROVIDER: S-EPMC4195855 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
van Thuijl Hinke F HF Scheinin Ilari I Sie Daoud D Alentorn Agusti A van Essen Hendrik F HF Cordes Martijn M Fleischeuer Ruth R Gijtenbeek Anja M AM Beute Guus G van den Brink Wimar A WA Meijer Gerrit A GA Havenith Miek M Idbaih Ahmed A Hoang-Xuan Khê K Mokhtari Karima K Verhaak Roel Gw RG van der Valk Paul P van de Wiel Mark A MA Heimans Jan J JJ Aronica Eleonora E Reijneveld Jaap C JC Wesseling Pieter P Ylstra Bauke B
Genome biology 20140923 9
<h4>Background</h4>The disease course of patients with diffuse low-grade glioma is notoriously unpredictable. Temporal and spatially distinct samples may provide insight into the evolution of clinically relevant copy number aberrations (CNAs). The purpose of this study is to identify CNAs that are indicative of aggressive tumor behavior and can thereby complement the prognostically favorable 1p/19q co-deletion.<h4>Results</h4>Genome-wide, 50 base pair single-end sequencing was performed to detec ...[more]