Upregulation of chemokine receptor CCR10 is essential for glioma proliferation, invasion and patient survival.
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ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC4196146 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Upregulation of chemokine receptor CCR10 is essential for glioma proliferation, invasion and patient survival.
Chen Lingchao L Liu Xing X Zhang Hai-Yan HY Du Wenzong W Qin Zhiyong Z Yao Yu Y Mao Ying Y Zhou Liangfu L
Oncotarget 20140801 16
Human gliomas are characterized by their invasion of normal brain structures irrespective of their grade of malignancy. Tumor cell invasion share many similarities with leukocyte trafficking, which is critically regulated by chemokines and their receptors. Here we report that the chemokine receptor CCR10 is highly expressed in human glioblastoma compared with control brain tissue. In vitro, signaling through CCL27-CCR10 mediates activation of p-Akt, and subsequently induces proliferation and inv ...[more]
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