Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC4196160 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Zhou Weihua W Xu Jie J Zhao Yongchao Y Sun Yi Y
Oncotarget 20140801 16
Sensitive to apoptosis gene (SAG), also known as RBX2, ROC2, or RNF7, is a RING component of SCF E3 ubiquitin ligases, which regulates cellular functions through ubiquitylation and degradation of many protein substrates. Although our previous studies showed that SAG is transcriptionally induced by redox, mitogen and hypoxia via AP-1 and HIF-1, it is completely unknown whether and how SAG is ubiquitylated and degraded. Here we report that NEDD4-1, a HECT domain-containing E3 ubiquitin ligase, bin ...[more]