Ontology highlight
ABSTRACT:
SUBMITTER: Murillo-Sauca O
PROVIDER: S-EPMC4196168 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Murillo-Sauca Oihana O Chung Man Ki MK Shin June Ho JH Karamboulas Christina C Kwok Shirley S Jung Young Ho YH Oakley Richard R Tysome James R JR Farnebo Lovisa O LO Kaplan Michael J MJ Sirjani Davud D Divi Vasu V Holsinger F Christopher FC Tomeh Chafeek C Nichols Anthony A Le Quynh T QT Colevas A Dimitrios AD Kong Christina S CS Uppaluri Ravindra R Lewis James S JS Ailles Laurie E LE Sunwoo John B JB
Oncotarget 20140801 16
Tumor-initiating cells (TICs) in squamous cell carcinoma of the head and neck (SCCHN) are best characterized by their surface expression of CD44. Although there is great interest in identifying strategies to target this population, no marker of these cells has been found to be functionally active. Here, we examined the expression of the purported marker of normal human oral epithelial stem cells, CD271. We show that CD271 expression is restricted to a subset of the CD44+ cells. Using xenograft a ...[more]