Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer.
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ABSTRACT:
SUBMITTER: Lai J
PROVIDER: S-EPMC4196172 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer.
Lai Jing J Nie Weiwei W Zhang Wenwen W Wang Yucai Y Xie Ruilian R Wang Yanru Y Gu Jun J Xu Jing J Song Wei W Yang Fang F Huang Guichun G Cao Peng P Guan Xiaoxiang X
Oncotarget 20140801 16
To understand the transcriptional regulation of p73 by promoter methylation and Nrf-2 in breast carcinogenesis, ChIP assay indicated that Nrf-2 can bind to both promoters and can activate the transcription of TAp73 and ΔNp73 in MCF-7 cell line, knockdown of Nrf-2 gene resulted in an abrogation of TAp73 and ΔNp73 expression in the cells transfected with sh-Nrf-2 as well as Nrf-2 knock out mouse model. However, we found Nrf-2 induced ΔNp73 expression was abolished with 5-aza-dC treatment, thus lea ...[more]
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