Ontology highlight
ABSTRACT:
SUBMITTER: Hedberg L
PROVIDER: S-EPMC419653 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20040510 20
Site-specific information about structural heterogeneities of the protein-folding transition-state ensemble is commonly derived from the scatter of the Brønsted plot through the individual values of = Delta logk(f)/Delta logK(D-N). Here, we provide a second level of site-specific detail in the transition-state analysis by demonstrating that the scatter of the Hammond plot is related to heterogeneities in the -value growth. That is, the extent of transition-state movement (Delta beta(++)) is prop ...[more]