Ontology highlight
ABSTRACT:
SUBMITTER: Landis GN
PROVIDER: S-EPMC419663 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20040510 20
Affymetrix GeneChips were used to measure RNA abundance for approximately 13,500 Drosophila genes in young, old, and 100% oxygen-stressed flies. Data were analyzed by using a recently developed background correction algorithm and a robust multichip model-based statistical analysis that dramatically increased the ability to identify changes in gene expression. Aging and oxidative stress responses shared the up-regulation of purine biosynthesis, heat shock protein, antioxidant, and innate immune r ...[more]