Ontology highlight
ABSTRACT:
SUBMITTER: Hughes RM
PROVIDER: S-EPMC4196877 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Hughes Robert M RM Lawrence David S DS
Angewandte Chemie (International ed. in English) 20140825 41
Genetically encoded, light-activatable proteins provide the means to probe biochemical pathways at specific subcellular locations with exquisite temporal control. However, engineering these systems in order to provide a dramatic jump in localized activity, while retaining a low dark-state background remains a significant challenge. When placed within the framework of a genetically encodable, light-activatable heterodimerizer system, the actin-remodelling protein cofilin induces dramatic changes ...[more]