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Direct action of endocrine disrupting chemicals on human sperm.

ABSTRACT: Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

SUBMITTER: Schiffer C

PROVIDER: S-EPMC4196979 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Direct action of endocrine disrupting chemicals on human sperm.

Schiffer Christian C Müller Astrid A Egeberg Dorte L DL Alvarez Luis L Brenker Christoph C Rehfeld Anders A Frederiksen Hanne H Wäschle Benjamin B Kaupp U Benjamin UB Balbach Melanie M Wachten Dagmar D Skakkebaek Niels E NE Almstrup Kristian K Strünker Timo T

EMBO reports 20140512 7

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, ...[more]

PMID: 24820036

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