Ontology highlight
ABSTRACT:
SUBMITTER: Falkenstein K
PROVIDER: S-EPMC4197084 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Falkenstein Kristin K De Lozanne Arturo A
Journal of cell science 20140801 Pt 20
Defects in human lysosomal-trafficking regulator (Lyst) are associated with the lysosomal disorder Chediak-Higashi syndrome. The absence of Lyst results in the formation of enlarged lysosome-related compartments, but the mechanism for how these compartments arise is not well established. Two opposing models have been proposed to explain Lyst function. The fission model describes Lyst as a positive regulator of fission from lysosomal compartments, whereas the fusion model identifies Lyst as a neg ...[more]