Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study.

ABSTRACT:

Background

Amyotrophic lateral sclerosis shares characteristics with some cancers, such as onset being more common in later life, progression usually being rapid, the disease affecting a particular cell type, and showing complex inheritance. We used a model originally applied to cancer epidemiology to investigate the hypothesis that amyotrophic lateral sclerosis is a multistep process.

Methods

We generated incidence data by age and sex from amyotrophic lateral sclerosis population registers in Ireland (registration dates 1995-2012), the Netherlands (2006-12), Italy (1995-2004), Scotland (1989-98), and England (2002-09), and calculated age and sex-adjusted incidences for each register. We regressed the log of age-specific incidence against the log of age with least squares re

SUBMITTER: Al-Chalabi A 

PROVIDER: S-EPMC4197338 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature