Ontology highlight
ABSTRACT:
SUBMITTER: Xu S
PROVIDER: S-EPMC4197410 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Xu Suhong S Chisholm Andrew D AD
Developmental cell 20141001 1
Reactive oxygen species (ROS) such as hydrogen peroxide are generated at wound sites and act as long-range signals in wound healing. The roles of other ROS in wound repair are little explored. Here, we reveal a cytoprotective role for mitochondrial ROS (mtROS) in Caenorhabditis elegans skin wound healing. We show that skin wounding causes local production of mtROS superoxide at the wound site. Inhibition of mtROS levels by mitochondrial superoxide-specific antioxidants blocks actin-based wound c ...[more]