Ontology highlight
ABSTRACT:
SUBMITTER: Vadnais C
PROVIDER: S-EPMC4197442 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Vadnais Charles C Shooshtarizadeh Peiman P Rajadurai Charles V CV Lesurf Robert R Hulea Laura L Davoudi Sayeh S Cadieux Chantal C Hallett Michael M Park Morag M Nepveu Alain A
Biology open 20140912 10
Autocrine activation of the Wnt/β-catenin pathway occurs in several cancers, notably in breast tumors, and is associated with higher expression of various Wnt ligands. Using various inhibitors of the FZD/LRP receptor complex, we demonstrate that some adenosquamous carcinomas that develop in MMTV-CUX1 transgenic mice represent a model for autocrine activation of the Wnt/β-catenin pathway. By comparing expression profiles of laser-capture microdissected mammary tumors, we identify Glis1 as a trans ...[more]