Ontology highlight
ABSTRACT:
SUBMITTER: Daoud G
PROVIDER: S-EPMC4197703 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Daoud Georges G Kempf Hervé H Kumar Deepak D Kozhemyakina Elena E Holowacz Tamara T Kim Dae-Won DW Ionescu Andreia A Lassar Andrew B AB
Development (Cambridge, England) 20141001 20
The relative timing of SHH and BMP signals controls whether presomitic mesoderm (PSM) cells will adopt either a chondrogenic or lateral plate mesoderm fate. Here we document that SHH-mediated induction of Nkx3.2 maintains the competence of somitic cells to initiate chondrogenesis in response to subsequent BMP signals by repressing BMP-dependent induction of GATA genes. Conversely, administration of BMP signals to PSM or forced expression of GATA family members in chick PSM explants blocks induct ...[more]