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How substrate specificity is imposed on a histone demethylase--lessons from KDM2A.


ABSTRACT: Histone lysine methylation and demethylation regulate histone methylation dynamics, which impacts chromatin structure and function. To read and erase the methylated histone residues, lysine demethylases must specifically recognize the histone sequences and methylated sites and discriminate the degree of these methylations. In this issue of Genes & Development, Cheng and colleagues (pp. 1758-1771) determine a crystal structure of histone lysine demethylase KDM2A that specifically targets lower degrees of H3K36 methylation. The results reveal the structural basis for H3K36 substrate specificity and suggest mechanisms of Lys36 demethylation. This KDM2A-H3K36 complex structure, coupled with functional studies, provides needed insight into the process and regulation of histone demethylation.

SUBMITTER: Tsai CL 

PROVIDER: S-EPMC4197959 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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How substrate specificity is imposed on a histone demethylase--lessons from KDM2A.

Tsai Chi-Lin CL   Shi Yang Y   Tainer John A JA  

Genes & development 20140801 16


Histone lysine methylation and demethylation regulate histone methylation dynamics, which impacts chromatin structure and function. To read and erase the methylated histone residues, lysine demethylases must specifically recognize the histone sequences and methylated sites and discriminate the degree of these methylations. In this issue of Genes & Development, Cheng and colleagues (pp. 1758-1771) determine a crystal structure of histone lysine demethylase KDM2A that specifically targets lower de  ...[more]

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