Ontology highlight
ABSTRACT:
SUBMITTER: Tsai CL
PROVIDER: S-EPMC4197959 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Tsai Chi-Lin CL Shi Yang Y Tainer John A JA
Genes & development 20140801 16
Histone lysine methylation and demethylation regulate histone methylation dynamics, which impacts chromatin structure and function. To read and erase the methylated histone residues, lysine demethylases must specifically recognize the histone sequences and methylated sites and discriminate the degree of these methylations. In this issue of Genes & Development, Cheng and colleagues (pp. 1758-1771) determine a crystal structure of histone lysine demethylase KDM2A that specifically targets lower de ...[more]