Playing TETris with DNA modifications.
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ABSTRACT:
SUBMITTER: Delatte B
PROVIDER: S-EPMC4198024 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Playing TETris with DNA modifications.
Delatte Benjamin B Deplus Rachel R Fuks François F
The EMBO journal 20140513 11
Methylation of the fifth carbon of cytosine was the first epigenetic modification to be discovered in DNA. Recently, three new DNA modifications have come to light: hydroxymethylcytosine, formylcytosine, and carboxylcytosine, all generated by oxidation of methylcytosine by Ten Eleven Translocation (TET) enzymes. These modifications can initiate full DNA demethylation, but they are also likely to participate, like methylcytosine, in epigenetic signalling per se. A scenario is emerging in which co ...[more]
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