Ontology highlight
ABSTRACT:
SUBMITTER: Allam R
PROVIDER: S-EPMC4198042 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Allam Ramanjaneyulu R Lawlor Kate E KE Yu Eric Chi-Wang EC Mildenhall Alison L AL Moujalled Donia M DM Lewis Rowena S RS Ke Francine F Mason Kylie D KD White Michael J MJ Stacey Katryn J KJ Strasser Andreas A O'Reilly Lorraine A LA Alexander Warren W Kile Benjamin T BT Vaux David L DL Vince James E JE
EMBO reports 20140702 9
A current paradigm proposes that mitochondrial damage is a critical determinant of NLRP3 inflammasome activation. Here, we genetically assess whether mitochondrial signalling represents a unified mechanism to explain how NLRP3 is activated by divergent stimuli. Neither co-deletion of the essential executioners of mitochondrial apoptosis BAK and BAX, nor removal of the mitochondrial permeability transition pore component cyclophilin D, nor loss of the mitophagy regulator Parkin, nor deficiency in ...[more]