Autophagy in microglia degrades extracellular ?-amyloid fibrils and regulates the NLRP3 inflammasome.
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ABSTRACT:
SUBMITTER: Cho MH
PROVIDER: S-EPMC4198361 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome.
Cho Mi-Hyang MH Cho Kwangmin K Kang Hoe-Jin HJ Jeon Eun-Young EY Kim Hun-Sik HS Kwon Hyung-Joon HJ Kim Hong-Mi HM Kim Dong-Hou DH Yoon Seung-Yong SY
Autophagy 20140722 10
Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological features of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades extracellular Aβ fibrils via the lysosomal system. Autophagy is a catabolic process that degrades native cellular components, however, the role of autophagy in Aβ degradation by microglia and its effects on AD are unknown. Here we demonstrate a novel role for autophagy in the clearance of extracellular Aβ fibrils b ...[more]
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