Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.
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ABSTRACT:
SUBMITTER: Neogi U
PROVIDER: S-EPMC4198440 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
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Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.
Neogi Ujjwal U Rao Shwetha D SD Bontell Irene I Verheyen Jens J Rao Vasudev R VR Gore Sagar C SC Soni Neelesh N Shet Anita A Schülter Eugen E Ekstrand Maria L ML Wondwossen Amogne A Kaiser Rolf R Madhusudhan Mallur S MS Prasad Vinayaka R VR Sonnerborg Anders A
AIDS (London, England) 20140901 15
A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being ...[more]
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