Ontology highlight
ABSTRACT:
SUBMITTER: Holler CJ
PROVIDER: S-EPMC4198456 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Holler Christopher J CJ Davis Paulina R PR Beckett Tina L TL Platt Thomas L TL Webb Robin L RL Head Elizabeth E Murphy M Paul MP
Journal of Alzheimer's disease : JAD 20140101 4
Recent genome wide association studies have implicated bridging integrator 1 (BIN1) as a late-onset Alzheimer's disease (AD) susceptibility gene. There are at least 15 different known isoforms of BIN1, with many being expressed in the brain including the longest isoform (iso1), which is brain-specific and localizes to axon initial segments and nodes of Ranvier. It is currently unknown what role BIN1 plays in AD. We analyzed BIN1 protein expression from a large number (n = 71) of AD cases and con ...[more]