Ontology highlight
ABSTRACT:
SUBMITTER: Wen SH
PROVIDER: S-EPMC4198687 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
BMC genomics 20141008
<h4>Background</h4>The power of the genome wide association studies starts to go down when the minor allele frequency (MAF) is below 0.05. Here, we proposed the use of Cohen's h in detecting disease associated rare variants. The variance stabilizing effect based on the arcsine square root transformation of MAFs to generate Cohen's h contributed to the statistical power for rare variants analysis. We re-analyzed published datasets, one microarray and one sequencing based, and used simulation to c ...[more]