Ontology highlight
ABSTRACT:
SUBMITTER: Nielsen AL
PROVIDER: S-EPMC419876 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Nielsen Anders Lade AL Jørgensen Poul P Lerouge Thierry T Cerviño Margarita M Chambon Pierre P Losson Régine R
Molecular and cellular biology 20040601 12
Haploinsufficiency of the NSD1 gene is a hallmark of Sotos syndrome, and rearrangements of this gene by translocation can cause acute myeloid leukemia. The NSD1 gene product is a SET-domain histone lysine methyltransferase that has previously been shown to interact with nuclear receptors. We describe here a novel NSD1-interacting protein, Nizp1, that contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C ...[more]