Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC419886 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Zhang Xiaohong X Wharton Walker W Yuan Zhigang Z Tsai Shih-Chang SC Olashaw Nancy N Seto Edward E
Molecular and cellular biology 20040601 12
Histone deacetylase (HDAC) inhibitors inhibit the proliferation of transformed cells in vitro, restrain tumor growth in animals, and are currently being actively exploited as potential anticancer agents. To identify gene targets of the HDAC inhibitor trichostatin A (TSA), we compared the gene expression profiles of BALB/c-3T3 cells treated with or without TSA. Our results show that TSA up-regulates the expression of the gene encoding growth-differentiation factor 11 (Gdf11), a transforming growt ...[more]