PICALM modulates autophagy activity and tau accumulation.
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ABSTRACT:
SUBMITTER: Moreau K
PROVIDER: S-EPMC4199285 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
PICALM modulates autophagy activity and tau accumulation.
Moreau Kevin K Fleming Angeleen A Imarisio Sara S Lopez Ramirez Ana A Mercer Jacob L JL Jimenez-Sanchez Maria M Bento Carla F CF Puri Claudia C Zavodszky Eszter E Siddiqi Farah F Lavau Catherine P CP Betton Maureen M O'Kane Cahir J CJ Wechsler Daniel S DS Rubinsztein David C DC
Nature communications 20140922
Genome-wide association studies have identified several loci associated with Alzheimer's disease (AD), including proteins involved in endocytic trafficking such as PICALM/CALM (phosphatidylinositol binding clathrin assembly protein). It is unclear how these loci may contribute to AD pathology. Here we show that CALM modulates autophagy and alters clearance of tau, a protein which is a known autophagy substrate and which is causatively linked to AD, both in vitro and in vivo. Furthermore, altered ...[more]
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