Ontology highlight
ABSTRACT:
SUBMITTER: Fuchs G
PROVIDER: S-EPMC4199367 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Fuchs Gilad G Hollander Dror D Voichek Yoav Y Ast Gil G Oren Moshe M
Genome research 20140721 10
Various histone modifications decorate nucleosomes within transcribed genes. Among these, monoubiquitylation of histone H2B (H2Bub1) and methylation of histone H3 on lysines 36 (H3K36me2/3) and 79 (H3K79me2/3) correlate positively with gene expression. By measuring the progression of the transcriptional machinery along genes within live cells, we now report that H2B monoubiquitylation occurs cotranscriptionally and accurately reflects the advance of RNA polymerase II (Pol II). In contrast, H3K36 ...[more]