Ontology highlight
ABSTRACT:
SUBMITTER: Yadava A
PROVIDER: S-EPMC4199514 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Yadava Anjali A Hall Cysha E CE Sullivan JoAnn S JS Nace Douglas D Williams Tyrone T Collins William E WE Ockenhouse Christian F CF Barnwell John W JW
PLoS neglected tropical diseases 20141016 10
We have previously reported that Vivax Malaria Protein 001 (VMP001), a vaccine candidate based on the circumsporozoite protein of Plasmodium vivax, is immunogenic in mice and rhesus monkeys in the presence of various adjuvants. In the present study, we evaluated the immunogenicity and efficacy of VMP001 formulated with a TLR9 agonist in a water-in-oil emulsion. Following immunization, the vaccine efficacy was assessed by challenging Aotus nancymaae monkeys with P. vivax sporozoites. Monkeys from ...[more]