Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC4200260 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Wang Hao H Yuan Yefeng Y Zhang Zhao Z Yan Hui H Feng Yaqin Y Li Wei W
The Journal of biological chemistry 20140825 42
DTNBP1 (dystrobrevin-binding protein 1), which encodes dysbindin-1, is one of the leading susceptibility genes for schizophrenia. Both dysbindin-1B and -1C isoforms are decreased, but the dysbindin-1A isoform is unchanged in schizophrenic hippocampal formation, suggesting dysbindin-1 isoforms may have distinct roles in schizophrenia. We found that mouse dysbindin-1C, but not dysbindin-1A, is localized in the hilar glutamatergic mossy cells of the dentate gyrus. The maturation rate of newborn neu ...[more]