Production of salidroside in metabolically engineered Escherichia coli.
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ABSTRACT:
SUBMITTER: Bai Y
PROVIDER: S-EPMC4200411 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Production of salidroside in metabolically engineered Escherichia coli.
Bai Yanfen Y Bi Huiping H Zhuang Yibin Y Liu Chang C Cai Tao T Liu Xiaonan X Zhang Xueli X Liu Tao T Ma Yanhe Y
Scientific reports 20141017
Salidroside (1) is the most important bioactive component of Rhodiola (also called as "Tibetan Ginseng"), which is a valuable medicinal herb exhibiting several adaptogenic properties. Due to the inefficiency of plant extraction and chemical synthesis, the supply of salidroside (1) is currently limited. Herein, we achieved unprecedented biosynthesis of salidroside (1) from glucose in a microorganism. First, the pyruvate decarboxylase ARO10 and endogenous alcohol dehydrogenases were recruited to c ...[more]
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