Zebrafish as a model to study live mucus physiology.
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ABSTRACT:
SUBMITTER: Jevtov I
PROVIDER: S-EPMC4200417 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Zebrafish as a model to study live mucus physiology.
Jevtov Irena I Samuelsson Tore T Yao Grace G Amsterdam Adam A Ribbeck Katharina K
Scientific reports 20141017
Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology. ...[more]
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