Ontology highlight
ABSTRACT:
SUBMITTER: Deelen P
PROVIDER: S-EPMC4200431 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Deelen Patrick P Menelaou Androniki A van Leeuwen Elisabeth M EM Kanterakis Alexandros A van Dijk Freerk F Medina-Gomez Carolina C Francioli Laurent C LC Hottenga Jouke Jan JJ Karssen Lennart C LC Estrada Karol K Kreiner-Møller Eskil E Rivadeneira Fernando F van Setten Jessica J Gutierrez-Achury Javier J Westra Harm-Jan HJ Franke Lude L van Enckevort David D Dijkstra Martijn M Byelas Heorhiy H van Duijn Cornelia M CM de Bakker Paul I W PI Wijmenga Cisca C Swertz Morris A MA
European journal of human genetics : EJHG 20140604 11
Although genome-wide association studies (GWAS) have identified many common variants associated with complex traits, low-frequency and rare variants have not been interrogated in a comprehensive manner. Imputation from dense reference panels, such as the 1000 Genomes Project (1000G), enables testing of ungenotyped variants for association. Here we present the results of imputation using a large, new population-specific panel: the Genome of The Netherlands (GoNL). We benchmarked the performance o ...[more]