Ontology highlight
ABSTRACT:
SUBMITTER: Yang WH
PROVIDER: S-EPMC4200751 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Yang Wei-Hung WH Tsai Chun-Hao CH Fong Yi-Chin YC Huang Yuan-Li YL Wang Shoou-Jyi SJ Chang Yung-Sen YS Tang Chih-Hsin CH
International journal of molecular sciences 20140905 9
Inflammatory response and articular destruction are common symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA). Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response. Yet, the mechanism of leptin interacting with the arthritic inflammatory response is unclear. This study finds that leptin increased expression of oncostatin M (OSM) in human osteoblasts in a concentration- and time-d ...[more]