Ontology highlight
ABSTRACT:
SUBMITTER: Ba X
PROVIDER: S-EPMC4200771 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Ba Xueqing X Aguilera-Aguirre Leopoldo L Rashid Qura Tul Ain Nmi QT Bacsi Attila A Radak Zsolt Z Sur Sanjiv S Hosoki Koa K Hegde Muralidhar L ML Boldogh Istvan I
International journal of molecular sciences 20140923 9
Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine's lowest redox potential among DNA bases. In mammalian cell ...[more]